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J. Russell Little, MD
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J. Russell Little, MD Professor Emeritus of Medicine and Molecular Microbiology Office Location: Barnes-Jewish Hospital North Dr. Little was born in Cheyenne, Wyoming. He received an A.B. in Zoology from Cornell University in Ithaca, New York and His M.D. from the University of Rochester. He was a medical intern at Strong Memorial Hospital in Rochester, New York. He began his long association with Washington University as a resident in medicine in 1957 and except for two years at the National Institutes of Health from 1959-1961 and a one year sabbatical as a Visiting Scientist at the Basel Institute of Immunology from 1972-1973, he has spent his whole professional life at Washington University. He was Chief Resident on the Ward Medicine Service at Barnes Hospital from 1961-1962 and was a Fellow with Herman Eisen in the Department of Microbiology from 1962-1964. Dr. Little was Director of the Infectious Diseases Division at Jewish Hospital before the merger of Barnes and Jewish Hospitals. He was made a Professor of Medicine at Washington University in 1976. He was also the Assistant Physician-in-Chief of the Department of Medicine at Jewish Hospital. Dr. Little has had a distinguished investigative career in immunology. His characterization of antibody structure and hapten binding in the 1960’s and early 1970’s presaged the development of monoclonal antibodies. In the mid-70’s he began investigations of thymocyte biology, and contributed to the description of the TL antigens, which were the first thymus-specific T cell markers. His investigative interests in immunology merged with his clinical interests in infectious diseases in elegant descriptions of the immunomodulation effects of Amphotericin B and the biochemistry of Histoplasma infection of macrophages. Dr. Little has served on the editorial boards of Molecular Immunology and The Journal of Immunology and has been honored with numerous awards including membership in Alpha Omega Alpha and the American Society of Clinical Investigation, and Fellowship in the Infectious Diseases Society of America. He also was the recipient of a Research Career Development Award from the National Institutes of Health. Dr. Little’s contributions to Washington University and Jewish Hospital are truly extraordinary. He has served both institutions on committees, as acting chair of the Department of Medicine at Jewish Hospital and in many advisory roles. In addition, he was a superb clinician and teacher and exemplifies the caring attitude that makes students, house officers, and most importantly, patients feel completely at ease and reassured in his presence. He was the supreme role model of the caring physician/teacher. Research Interests Ongoing areas of clinical interest include:
Division of Infectious Diseases
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